Diabetes & Metabolism Journal

Original Articles

Epidemiology
Depression and Mortality in People with Type 2 Diabetes Mellitus, 2003 to 2013: A Nationwide Population-Based Cohort Study: Jong-Hyun Jeong, Yoo Hyun Um, Seung-Hyun Ko, Jong-Heon Park, Joong-Yeol Park, Kyungdo Han, Kyung-Soo Ko; Diabetes Metab J. 2017;41(4):296-302. Published online August 3, 2017; DOI: https://doi.org/10.4093/dmj.2017.41.4.296

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Background

Previous reports have demonstrated a bidirectional relationship between depression and diabetes mellitus (DM), accentuating a need for more intensive depression screening in DM patients. There is a relative paucity of data on the mortality of depressed DM patients in Korea.

Methods

Retrospective data from January 2003 to December 2013 were collected for adult type 2 diabetes mellitus (T2DM) patients older than 30 years using the National Health Information database maintained by the Korean National Health Insurance Service (NHIS). Demographic characteristics were analyzed with descriptive statistics, and the annual prevalence of depression was estimated. Mortality rates and hazard ratios for each age group (stratified into six age groups) of patients diagnosed with T2DM in 2003 were estimated using a Cox proportional hazard method, with the Kaplan-Meier cumulative survival curve showing the overall survival rates according to the T2DM status until the given year of 2013.

Results

The annual prevalence of depression was consistently higher in T2DM group from 2003 to 2013. The mortality hazard ratio was higher in the depressed in all age groups, and the risk was higher in male groups and in younger-aged groups.

Conclusion

Depression was significantly associated with a high mortality risk in T2DM patients; hence, a more systematic surveillance of T2DM patients to identify risk factors for depression might contribute significantly to reducing mortality risk in this group of patients.

Citations

Citations to this article as recorded by

An observational study to evaluate the awareness of drug treatment, prescription pattern, adverse drug reactions, and adherence in patients of major depressive disorder
Urwashi Indrakumar Parmar, Pranali Puradkar, Kranti Kadam, Firoz Tadavi, Snehalata Gajbhiye, Shirish Joshi, Amitoj Sohal
Perspectives in Clinical Research.2024; 15(2): 59. CrossRef
Association between type 2 diabetes mellitus and depression among Korean midlife women: a cross-sectional analysis study
You Lee Yang, Eun-Ok Im, Yunmi Kim
BMC Nursing.2023;[Epub] CrossRef
The Effect of Exercise Interventions to Improve Psychosocial Aspects and Glycemic Control in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Gholam Rasul Mohammad Rahimi, Reza Aminzadeh, Amin Azimkhani, Vahid Saatchian
Biological Research For Nursing.2022; 24(1): 10. CrossRef
Is it time to consider depression as a major complication of type 2 diabetes? Evidence from a large population-based cohort study
Rossella Messina, Marica Iommi, Paola Rucci, Chiara Reno, Maria Pia Fantini, Carlotta Lunghi, Mattia Altini, Francesca Bravi, Simona Rosa, Antonio Nicolucci, Paolo Di Bartolo
Acta Diabetologica.2022; 59(1): 95. CrossRef
The effects of smoking habit change on the risk of depression–Analysis of data from the Korean National Health Insurance Service
Ga Eun Kim, Min-ho Kim, Weon-Jeon Lim, Soo In Kim
Journal of Affective Disorders.2022; 302: 293. CrossRef
Association Between Diabetic Retinopathy and Insomnia Risk: A Nationwide Population-Based Study
Yoo Hyun Um, Tae-Won Kim, Jong-Hyun Jeong, Seung-Chul Hong, Ho-Jun Seo, Kyung-Do Han
Frontiers in Endocrinology.2022;[Epub] CrossRef
Implication of Melanocortin Receptor Genes in the Familial Comorbidity of Type 2 Diabetes and Depression
Mutaz Amin, Jurg Ott, Rongling Wu, Teodor T. Postolache, Claudia Gragnoli
International Journal of Molecular Sciences.2022; 23(15): 8350. CrossRef
Nutritional importance of tryptophan for improving treatment in depression and diabetes
Darakhshan Jabeen Haleem
Nutrition Reviews.2022; 81(1): 133. CrossRef
Depression but not non-persistence to antidiabetic drugs is associated with mortality in type 2 diabetes: A nested case-control study
Carlotta Lunghi, Arsène Zongo, Isabelle Tardif, Éric Demers, Joël Désiré Relwende Diendéré, Line Guénette
Diabetes Research and Clinical Practice.2021; 171: 108566. CrossRef
Single-session acceptance and commitment therapy (ACT) interventions for patients with chronic health conditions: A systematic review and meta-analysis
Cara Dochat, Jennalee S. Wooldridge, Matthew S. Herbert, Michael W. Lee, Niloofar Afari
Journal of Contextual Behavioral Science.2021; 20: 52. CrossRef
Population segmentation of type 2 diabetes mellitus patients and its clinical applications - a scoping review
Jun Jie Benjamin Seng, Amelia Yuting Monteiro, Yu Heng Kwan, Sueziani Binte Zainudin, Chuen Seng Tan, Julian Thumboo, Lian Leng Low
BMC Medical Research Methodology.2021;[Epub] CrossRef
Increased Risk of Cardiovascular Disease and Mortality in Patients with Diabetes and Coexisting Depression: A Nationwide Population-Based Cohort Study
Inha Jung, Hyemi Kwon, Se Eun Park, Kyung-Do Han, Yong-Gyu Park, Yang-Hyun Kim, Eun-Jung Rhee, Won-Young Lee
Diabetes & Metabolism Journal.2021; 45(3): 379. CrossRef
Spiritual intelligence, mindfulness, emotional dysregulation, depression relationship with mental well-being among persons with diabetes during COVID-19 pandemic
Wojujutari Kenni Ajele, Teslim Alabi Oladejo, Abimbola A. Akanni, Oyeyemi Bukola Babalola
Journal of Diabetes & Metabolic Disorders.2021; 20(2): 1705. CrossRef
Altered circulatory levels of miR-128, BDNF, cortisol and shortened telomeres in patients with type 2 diabetes and depression
Paramasivam Prabu, Subramani Poongothai, Coimbatore Subramanian Shanthirani, Ranjit Mohan Anjana, Viswanathan Mohan, Muthuswamy Balasubramanyam
Acta Diabetologica.2020; 57(7): 799. CrossRef
Intervention Strategies for Prevention of Comorbid Depression Among Individuals With Type 2 Diabetes: A Scoping Review
Eva Guérin, Hamdi Jaafar, Lisa Amrani, Denis Prud'homme, Céline Aguer
Frontiers in Public Health.2019;[Epub] CrossRef
Association between use of oral hypoglycemic agents in Japanese patients with type 2 diabetes mellitus and risk of depression: A retrospective cohort study
Hayato Akimoto, Kotoe Tezuka, Yayoi Nishida, Tomohiro Nakayama, Yasuo Takahashi, Satoshi Asai
Pharmacology Research & Perspectives.2019;[Epub] CrossRef
Depression and cardiovascular disease in elderly: Current understanding
Yaxin Zhang, Yujing Chen, Lina Ma
Journal of Clinical Neuroscience.2018; 47: 1. CrossRef
Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis
Seung-Hyun Ko, Kyungdo Han, Yong-ho Lee, Junghyun Noh, Cheol-Young Park, Dae-Jung Kim, Chang Hee Jung, Ki-Up Lee, Kyung-Soo Ko
Diabetes & Metabolism Journal.2018; 42(2): 93. CrossRef
Depression and Mortality in Type 2 Diabetes Mellitus
Seo Young Lee, Sung Hee Choi
Diabetes & Metabolism Journal.2017; 41(4): 263. CrossRef

Intensive Individualized Reinforcement Education Is Important for the Prevention of Hypoglycemia in Patients with Type 2 Diabetes: Yun-Mi Yong, Kyung-Mi Shin, Kang-Min Lee, Jae-Young Cho, Sun-Hye Ko, Min-Hyang Yoon, Tae-Won Kim, Jong-Hyun Jeong, Yong-Moon Park, Seung-Hyun Ko, Yu-Bae Ahn; Diabetes Metab J. 2015;39(2):154-163. Published online March 10, 2015; DOI: https://doi.org/10.4093/dmj.2015.39.2.154

3,952 View
40 Download
17 Web of Science
20 Crossref

Abstract PDF Supplementary Material PubReader

Background

We investigated whether an intensive individualized reinforcement education program could influence the prevention of hypoglycemic events in patients with type 2 diabetes.

Methods

From March 2013 to September 2013, patients aged 35 to 75 years with type 2 diabetes who had not previously participated in diabetes education, and treated with insulin or a sulfonylurea-containing regimen were included in the study. After structured group education, the patients assigned to the intensive individualized education group (IT) were requested to visit for reinforcement. All subjects in the IT were encouraged to self-manage dose adjustments. Participants in both groups (control group [CG, group education only; n=22] and IT [n=24]) attended follow-up visits at 2, 8, 12, and 24 weeks. At each visit, all patients were asked whether they had experienced hypoglycemia.

Results

The total study population consisted of 20 men (43.5%; mean age and diabetic duration of 55.9±11.0 and 5.1±7.3 years, respectively). At 24 weeks, there were no significant differences in hemoglobin A1c values between the CG and IT. The total number of hypoglycemic events per patient was 5.26±6.5 in the CG and 2.58±2.3 times in the IT (P=0.004). Adherence to lifestyle modification including frequency of exercise, self-monitoring of blood glucose, or dietary habit was not significantly different between the groups. However, adherence to hypoglycemia management, especially the dose adjustment of medication, was significantly higher in the IT compared with the CG.

Conclusion

Compared with the structured group education, additional IT resulted in additional benefits in terms of avoidance of hypoglycemia and treating hypoglycemia in patients with type 2 diabetes.

Citations

Citations to this article as recorded by

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Huda Y. Almomani, Carlos Rodriguez Pascual, Paul Grassby, Keivan Ahmadi
Research in Social and Administrative Pharmacy.2023; 19(2): 322. CrossRef
A Cross-Sectional study on risk factors for severe hypoglycemia among Insulin-Treated elderly type 2 diabetes Mellitus (T2DM) patients in Singapore
Michelle Shi Min Ko, Wai Kit Lee, Li Chang Ang, Su-Yen Goh, Yong Mong Bee, Ming Ming Teh
Diabetes Research and Clinical Practice.2022; 185: 109236. CrossRef
Management Status of Patients with Type 2 Diabetes Mellitus at General Hospitals in Korea: A 5-Year Follow-Up Study
Jin Hee Jung, Jung Hwa Lee, Hyang Mi Jang, Young Na, Hee Sun Choi, Yeon Hee Lee, Yang Gyo Kang, Na Rae Kim, Jeong Rim Lee, Bok Rye Song, Kang Hee Sim
The Journal of Korean Diabetes.2022; 23(1): 64. CrossRef
Anti-hyperglycemic Medication Compliance: A Quality Assurance Project
Rayan Mamoon, Md Y Mamoon, Debbie Hermanstyne, Issac Sachmechi
Cureus.2022;[Epub] CrossRef
Randomised controlled trial of pharmacist-led patient counselling in controlling hypoglycaemic attacks in older adults with type 2 diabetes mellitus (ROSE-ADAM): A study protocol of the SUGAR intervention
Huda Y. Almomani, Carlos Rodriguez Pascual, Sayer I. Al-Azzam, Keivan Ahmadi
Research in Social and Administrative Pharmacy.2021; 17(5): 885. CrossRef
Severe hypoglycemia as a preventable risk factor for cardiovascular disease in patients with type 2 diabetes mellitus
Soo-Yeon Choi, Seung-Hyun Ko
The Korean Journal of Internal Medicine.2021; 36(2): 263. CrossRef
Type 2 diabetes patients’ views on prevention of hypoglycaemia – a mixed methods study investigating self-management issues and self-identified causes of hypoglycaemia
Stijn Crutzen, Tessa van den Born-Bondt, Petra Denig, Katja Taxis
BMC Family Practice.2021;[Epub] CrossRef
Cross‐sectional analysis of emergency hypoglycaemia and outcome predictors among people with diabetes in an urban population
Chukwuma Uduku, Valentina Pendolino, Ian Godsland, Nick Oliver, Monika Reddy, Rachael T. Fothergill
Diabetic Medicine.2021;[Epub] CrossRef
Short-term efficacy of high intensity group and individual education in patients with type 2 diabetes: a randomized single-center trial
R. Reale, A. Tumminia, L. Romeo, N. La Spina, R. Baratta, G. Padova, L. Tomaselli, L. Frittitta
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Ahmed Iqbal, Simon R. Heller
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Yasuaki Hayashino, Satoru Tsujii, Hitoshi Ishii
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Byung-Wan Lee, Jin Hwa Kim, Seung-Hyun Ko, Kyu-Yeon Hur, Nan-Hee Kim, Sang Youl Rhee, Hyun Jin Kim, Min Kyong Moon, Seok-O Park, Kyung Mook Choi
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Seung-Hyun Ko, Kyu-Yeon Hur, Sang Youl Rhee, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Hyun Jin Kim, Kyung Mook Choi, Jin Hwa Kim
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Insulin therapy for adult patients with type 2 diabetes mellitus: a position statement of the Korean Diabetes Association, 2017
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The Korean Journal of Internal Medicine.2017; 32(6): 967. CrossRef
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